With the inter-dimensional teams still shuffled and scrambled from the previous issue, the Ghostbusters are managing a Firehouse overrun with Slimers from multiple dimensions. Walter Peck and Jenny Moran field the administrative chaos while the teams are deployed across several missions simultaneously.
One team encounters the Headless Horseman and a haunted location tied to the Wander Hills Orphanage, which burned down in 1920 after lightning struck and caused a fire. Another crew investigates the Helsingor Brewery in Dimension 75-B. In a supernatural game of chess, Eduardo Rivera of Dimension 68-E faces Death, with the opening move being the Queen's Pawn to D4 (the Queen's Pawn Game). Egon Spengler and the team must also contend with the Hungry Manitou conjuring the Giant Murder Clown and Fire Goblins menacing another front.
Meanwhile, the larger threat comes into focus. Tiamat, who previously made a deal to leave the Ghostbusters' earth, is looking for loopholes in that agreement. Her father Koza'Rai appears and warns her she will regret her decision, referencing the Ghostbusters' victory over him during the events of Ghostbusters: Displaced Aggression. Koza'Rai reveals that Tiamat's attention was caught by the capture of The Collectors in Teenage Mutant Ninja Turtles/Ghostbusters Volume 2 #5. The issue closes with Holtzmann being grabbed and Ron Alexander injured.
Cover A (Diamond Order Code: MAY180714, regular cover): Depicts Samuel Hazer from Ghostbusters: Sanctum of Slime, Kylie Griffin from Extreme Ghostbusters, Jenny Moran, Winston Zeddemore, Mike the Golem from Dimension 68-V, and the Marine Ecto-8 from Ghostbusters: The Video Game.
Cover B (subscription): Features Abby Yates with her helmet from the 2016 film (her flightsuit carries the Ghostbusters II logo), Egon Spengler, the Real Ghostbusters Egon, the Extreme Ghostbusters Egon, and Roland Jackson from Extreme Ghostbusters. The cover also showcases Kenner collectibles: the Ecto-Plazm set and three included ghosts, the PKE Meter that came with the Proton Pack, and the unreleased Kenner Egon's Lab toy.
Cover RI (retailer incentive): Features Egon Spengler and Slimer from The Real Ghostbusters alongside Jillian Holtzmann from the 2016 film. Holtzmann is holding her modified Ghost Trap as seen in the Answer the Call comic.
